Prof. Dr. Karl H. Plate
Edinger Institute
Goethe University Medical School
Frankfurt, Germany
Tel (49)-[0]69-6301-6042
Fax (49)-[0]69-679487
E-Mail: plate@em.uni-frankfurt.de
Scientific Focus
Brain Tumor Biology
Methods
Histology, Genome-wide DNA-methylation, whole exome sequencing, multiplex-immunohistochemistry, Spatial Transcriptomics. Animal models for glioma and brain metastases
Selected Publications
Capper D, … Plate KH, … et al. DNA methylation-based classification of central nervous system tumours. Nature. 2018 Mar 22;555(7697):469-474. doi:10.1038/nature26000. Epub 2018 Mar 14.PMID: 29539639
Bunse L, … Plate KH, …et al. Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate. Nat Med. 2018 Aug;24(8):1192-1203. doi: 10.1038/s41591-018-0095-6. Epub 2018 Jul 9.
PMID: 29988124
Di Tacchio M, Macas J, Weissenberger J, Sommer K, Bähr O, Steinbach JP, Senft C, Seifert V, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Scheel AH, Büttner R, Grauer OM, Schittenhelm J, Tabatabai G, Harter PN, Günther S, Devraj K, Plate KH, Reiss Y. Tumor Vessel Normalization, Immunostimulatory Reprogramming, and Improved Survival in Glioblastoma with Combined Inhibition of PD-1, Angiopoietin-2, and VEGF. Cancer Immunol Res. 2019 Dec;7(12):1910-1927. doi: 10.1158/2326-6066.CIR-18-0865. Epub 2019 Oct 9. PMID: 31597643
Katja Niesel, Michael Schulz, Julian Anthes Tijna Alekseeva, Jadranka Macas, Anna Salamero-Boix, Aylin Möckl, Timm Oberwahrenbrock, Marco Lolies, Stefan Stein, Karl H Plate , Yvonne Reiss , Franz Rödel, Lisa Sevenich. The immune suppressive microenvironment affects efficacy of radio-immunotherapy in brain metastasis. EMBO Mol Med 2021 May 7;13(5):e13412. doi: 10.15252/emmm.202013412. Epub 2021 Mar 23PMID: 33755340
Florian Klemm, Aylin Möckl, Anna Salamero-Boix, Tijna Alekseeva, Alexander Schäffer, Michael Schulz, Katja Niesel, Roeltje R. Maas, Marie Groth, Benelita T. Elie, Robert L. Bowman, Monika E. Hegi, Roy T. Daniel, Pia S. Zeiner, Jenny Zinke, Patrick N. Harter, Karl H. Plate, Johanna A. Joyce & Lisa Sevenich. Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis. Nature Cancer volume 2, pages 1086–1101 (2021)